Armon adibi steroids and alcohol
•
Inhalt (1011 Artikel)
Pre-operative anxiolysis in children through a combined pharmacological therapy with hydroxyzine and a non-pharmacological distraction technique with a clown (SONRISA): study protocol for randomised double-blind clinical trial
- Open Access
- Study protocol
Esther Aleo Luján, Amanda Lopez-Picado, Ana Rivas, Belén Joyanes Abancens, Marina Laura Rodríguez Rojo, Patricia Fernández García, Carmen Soto Beauregard, Jaime Rodríguez Alarcón, Carlos González Perrino, Borja San Pedro de Urquiza, Eva Arias, Diamelis Rodriguez, Carmen Esteban Polonio, Maria José Torrejón
A trial protocol for the effectiveness of digital interventions for preventing depression in adolescents: The Future Proofing Study
- Open Access
- Study protocol
Aliza Werner-Seidler, Kit Huckvale, Mark E. Larsen, Alison L. Calear, Kate Maston, Lara Johnston, Michelle Torok, Bridianne O’Dea, Philip J. Batterham, Susanne Schweizer, S. Rachel Skinner, Katharine Steinbeck, Julie Ratcliffe, Ju-Lee Oei, George Patton, Iana Wong, Joanne Beames, Quincy J. J. Wong, Raghu Lingam, Katherine Boydell, Allison M. Salmon, Nicole Cockayne, Andrew Mackinnon, Helen Christensen
Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled
•
Page :S41
Babette W. Swallow, A.J. Gerard Jansen, Eric A.P. Steegers, Wim C.J. Hop, Marie-Louise Essink-Bot, Carin A. Uyl-de Groot, Dimitri N.M. Papatsonis, Bettina M.C. Akerboom, Godfried C.H. Metz, Henk A. Bremer, Aren J. precursor Loon, Raid H. Stigter, Joris A.M. van flight Post, Marcel van Alphen, Martina Porath, Robbert J.P. Rijnders, Marc E.A. Spaanderman, Daniela H. Schippers, Fund W.M. Bloemenkamp, Kim Hook up. Boers, Hubertina C.J. Scheepers, Frans J.M.E. Roumen, Anneke Kwee, Nico W.E. Schuitemaker, Ben Willem J. Mol, Dick J. van Rhenen, Johannes J. Duvekot
PlanPlan•
Abstract
The management of neurological disorders heavily relies on neurotherapeutic drugs, but notable concerns exist regarding their possible negative effects on reproductive health. Traditional preclinical models often fail to accurately predict reprotoxicity, highlighting the need for more physiologically relevant systems. Organoid models represent a promising approach for concurrently studying neurotoxicity and reprotoxicity, providing insights into the complex interplay between neurotherapeutic drugs and reproductive systems. Herein, we have examined the molecular mechanisms underlying neurotherapeutic drug-induced reprotoxicity and discussed experimental findings from case studies. Additionally, we explore the utility of organoid models in elucidating the reproductive complications of neurodrug exposure. Have discussed the principles of organoid models, highlighting their ability to recapitulate neurodevelopmental processes and simulate drug-induced toxicity in a controlled environment. Challenges and future perspectives in the field have been addressed with a focus on advancing organoid technologies to improve reprotoxicity assessment and enhance drug safety screening. This review underscores the importance of organoid models in unraveling the complex relationship bet