Gopimohan biography of abraham
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Abstract
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology. Key elements that respond to various signal pathways are the myosin II regulatory light chains (MLC), which participate in actin-myosin contraction by modulating the ATPase activity and consequent contractile force generation mediated by myosin heavy chain heads. Considerable effort has focussed on the role of MLC kinases, and yet the contributions of the myotonic dystrophy-related Cdc42-binding kinases (MRCK) proteins in MLC phosphorylation and cytoskeleton regulation have not been well characterized. In contrast to the closely related ROCK1 and ROCK2 kinases that are regulated by the RhoA and RhoC GTPases, there is relatively little information about the CDC42-regulated MRCKα, MRCKβ and MRCKγ members of the AGC (PKA, PKG and PKC) kinase family. As well as differences in upstream activation pathways, MRCK and ROCK kinases apparently differ in the way that they spatially regulate MLC phosphorylation, which ultimately affects their influence on the organization and dynamics of the actin-myosin cytoskeleton. In this review, we will summarize the MRCK protein structures, expression patterns, sma
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Name
Country
Association
Fella Arbaoui
Algeria
University
Samir Bachouche
Algeria
National Center of Research and Development of Fishing and Aquaculture (CNRDPA)
Ahmed Inal
Algeria
National Center for Research and Development of Fisheries and Aquaculture
Salah Eddine Laouassa
Algeria
Univercity of Science and Thechnology Houari Boumediene (USTHB)
Abdelkader Rechidi
Algeria
PlanEco
Hazem Salah Eddine
Algeria
University Houari Boumedien
Val Brown
American Samoa
National Marine Sanctuary of American Samoa
Paulo Coelho
Angola
Instituto Nacional de Investigação Pesqueira e Marinha
Sonia Silva
Angola
Universidade Agostinho Neto
Ruleo Camacho
Antigua and Barbuda
National Parks Authority
Jermel Charles
Antigua and Barbuda
Department of Analytical Services
Linroy Christian
Antigua and Barbuda
Department of Analytical Services
Lisandro Arbilla
Argentina
UBA-CONICET-SHN
Carla Florencia Berghoff
Argentina
Instituto Nacional de Investigación y Desarrollo Pesquero (INIDEP)- Paseo Victoria Ocampo Nº1, Escollera Norte B7602HSA Mar del Plata, Buenos Aires, Argentina
Alejandro Bianchi
Argentina
Servcio de Hidrografía naval
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